Literature summary for 3.4.22.54 extracted from

Moretti, D.; Del Bello, B.; Allavena, G.; Corti, A.; Signorini, C.; Maellaro, E.
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells (2015), PLoS ONE, 10, e0117258 .

Search for more literature for 3.4.22.54

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
intracellular	-	Homo sapiens	5622	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P20807	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell line	two novel splicing variants (hMp78 and hMp84) of calpain-3 gene (CAPN3) have a significant lower expression in vertical growth phase melanomas and, even lower, in metastases, compared to benign nevi	Homo sapiens	-
skeletal muscle	the enzyme is predominantly expressed in skeletal muscle	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	calpain-3 down-regulation can be regarded as a mechanism contributing to melanoma progression. Overexpression of the calpain-3 splicing variant hMp84 in A375 cells or HT-144 cells causes inhibition of cell proliferation, cell death, and increase of both ROS levels and F2-isoprostanes	Homo sapiens

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Release 2023.1 (January 2023)