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Literature summary for 3.4.22.54 extracted from

  • Michel, L.Y.; Hoenderop, J.G.; Bindels, R.J.
    Calpain-3-mediated regulation of the Na+-Ca2+ exchanger isoform 3 (2016), Pflugers Arch., 468, 243-255 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.54

Protein Variants

Protein Variants Comment Organism
C129S inactive mutant enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P20807
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
CAPN3
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction loss of calpain-3 (CAPN3) activity leads to limb-girdle muscular dystrophy 2A. Calpain-3 mediates regulation of the Na+-Ca2+ exchanger isoform 3. The loss of regulation of Na+-Ca2+ exchanger isoform 3 (NCX3) by calpain-3 can be implicated in diverse muscular pathologies such as the limb-girdle muscular dystrophy 2A Homo sapiens