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Literature summary for 3.4.22.54 extracted from
- Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein (2015), J. Biol. Chem., 290, 996-1004.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | calmodulin binds the calpain 3 non-catalytic domain C2L and promotes enzyme activation | Mus musculus |  |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C129S | inactive | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 94000 | - |
x * 94000, full-length enzyme, SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q64691 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| titin + H2O | - |
Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 94000, full-length enzyme, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain 3 | - |
Mus musculus |
| CAPN3 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | mutations of calpain 3 cause limb-girdle dystrophy 2A | Mus musculus |
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Release 2023.1 (January 2023)
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