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Literature summary for 3.4.22.54 extracted from

  • Laure, L.; Daniele, N.; Suel, L.; Marchand, S.; Aubert, S.; Bourg, N.; Roudaut, C.; Duguez, S.; Bartoli, M.; Richard, I.
    A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-?B pathway in skeletal muscle (2010), FEBS J., 277, 4322-4337.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in NIH-3T3 fibroblasts Homo sapiens

Protein Variants

Protein Variants Comment Organism
C129S inactive Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P20807
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cardiac ankyrin repeat protein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
calpain 3
-
Homo sapiens

General Information

General Information Comment Organism
metabolism calpain 3 has a central role in the regulation of the important cell fate-governing nuclear factor-kappaB pathway. Calpain 3-mediated cardiac ankyrin repeat protein cleavage strengthens its interaction with titin N2A Homo sapiens