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Literature summary for 3.4.22.54 extracted from

  • Hayashi, C.; Ono, Y.; Doi, N.; Kitamura, F.; Tagami, M.; Mineki, R.; Arai, T.; Taguchi, H.; Yanagida, M.; Hirner, S.; Labeit, D.; Labeit, S.; Sorimachi, H.
    Multiple molecular interactions implicate connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle (2008), J. Biol. Chem., 23, 14801-14814.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Homo sapiens
expression in COS-7 cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
connectin + H2O Homo sapiens p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions ?
-
?
connectin + H2O Mus musculus p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions ?
-
?
MARP2/Ankrd2 + H2O Homo sapiens
-
?
-
?
MARP2/Ankrd2 + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P20807
-
-
Mus musculus Q64691
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Homo sapiens
-
skeletal muscle
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
connectin + H2O p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions Homo sapiens ?
-
?
connectin + H2O p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions Mus musculus ?
-
?
MARP2/Ankrd2 + H2O
-
Homo sapiens ?
-
?
MARP2/Ankrd2 + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
p94/calpain 3
-
Homo sapiens
p94/calpain 3
-
Mus musculus