Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | of normal and of patients with limb girdle muscular dystrophy. Screening of calpain-3 autolytic activity in limb girdle muscular dystrophy muscle. Missense mutations localized in calpain-3 domains II and III would impair its autolytic activity, possibly because of the charge variation in the residues involved in internal salt bridges. This would finally result in a reduced sensitivity to Ca2+-ions. The pathogenetic effect of these mutations may be understood in terms of impaired communications between protein interdomains | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
calpain-3 | - |
Homo sapiens |