Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
94000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | loss-of-function mutations in the calpain 3 gene are associated with limb-girdle muscular dystrophy type 2A. Through the absence of cleavage of the cytoskeletal proteins, calpain 3 deficiency leads to abnormal sarcomers, impairment of muscle contractile capacity and death of muscle fibers | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | fast-twitch and slow-twitch fibers. In this tissue, calpain 3 localizes at several regions of the sarcomere through binding to the giant protein, titin | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ezrin + H2O | - |
Homo sapiens | ? | - |
? | |
filamin C + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | loss-of-function mutations in the calpain 3 gene are associated with limb-girdle muscular dystrophy type 2A. Through the absence of cleavage of the cytoskeletal proteins, calpain 3 deficiency leads to abnormal sarcomers, impairment of muscle contractile capacity and death of muscle fibers | Homo sapiens | ? | - |
? | |
additional information | cytoskeletal proteins are one class of its substrates | Homo sapiens | ? | - |
? | |
talin + H2O | - |
Homo sapiens | ? | - |
? | |
titin + H2O | - |
Homo sapiens | ? | - |
? | |
vinexin + H2O | - |
Homo sapiens | ? | - |
? |