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Literature summary for 3.4.22.54 extracted from

  • Welm, A.L.; Timchenko, N.A.; Ono, Y.; Sorimachi, H.; Radomska, H.S.; Tenen, D.G.; Lekstrom-Himes, J.; Darlington, G.J.
    C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells (2002), J. Biol. Chem., 277, 33848-33856.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclin A + H2O Mus musculus calpain 3-mediated cleavage of cyclin A in dividing myeloid pregenitor cells is important for the onset of differentiation additional information production of a truncated product that lacks the N-terminal destruction box required for its degradation at the end of mitosis. The cleaved form of cyclin A retains the cyclin-dependent kinase binding domain and forms active complexes with cdk2 ?
cyclin A + H2O Homo sapiens calpain 3-mediated cleavage of cyclin A in dividing myeloid pregenitor cells is important for the onset of differentiation additional information production of a truncated product that lacks the N-terminal destruction box required for its degradation at the end of mitosis. The cleaved form of cyclin A retains the cyclin-dependent kinase binding domain and forms active complexes with cdk2 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
marrow cell
-
 Mus musculus
-
marrow cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclin A + H2O
-
 Mus musculus ?
-
 ?
cyclin A + H2O
-
 Homo sapiens ?
-
 ?
cyclin A + H2O calpain 3-mediated cleavage of cyclin A in dividing myeloid pregenitor cells is important for the onset of differentiation Mus musculus additional information production of a truncated product that lacks the N-terminal destruction box required for its degradation at the end of mitosis. The cleaved form of cyclin A retains the cyclin-dependent kinase binding domain and forms active complexes with cdk2 ?
cyclin A + H2O calpain 3-mediated cleavage of cyclin A in dividing myeloid pregenitor cells is important for the onset of differentiation Homo sapiens additional information production of a truncated product that lacks the N-terminal destruction box required for its degradation at the end of mitosis. The cleaved form of cyclin A retains the cyclin-dependent kinase binding domain and forms active complexes with cdk2 ?