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Literature summary for 3.4.22.54 extracted from

  • Guyon, J.R.; Kudryashova, E.; Potts, A.; Dalkilic, I.; Brosius, M.A.; Thompson, T.G.; Beckmann, J.S.; Kunkel, L.M.; Spencer, M.J.
    Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans (2003), Muscle Nerve, 28, 472-483.
    View publication on PubMed
Search for more literature for 3.4.22.54

Cloned(Commentary)

Cloned (Comment) Organism
COS-7 cells are transfected with C3 construct ssubcloned into pcDNA 3.1 and/or a C-terminal human FLNC construct subcloned into pCMV Tag2B Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
C129S it is difficult to efficiently express the mutant enzyme C129S Rattus norvegicus
W99R/I135T/K347E/F779L mutant enzyme form does not autolyze and does not cleave filamin C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
filamin C + H2O Mus musculus enzyme specifically cleaves the C-terminal portion in living cells. Filamin C may be an in vivo substrate to c3, functioning to regulate protein-protein interactions with the sarcoglycans ?
-
 ?
filamin C + H2O Rattus norvegicus enzyme specifically cleaves the C-terminal portion in living cells. Filamin C may be an in vivo substrate to c3, functioning to regulate protein-protein interactions with the sarcoglycans ?
-
 ?
additional information Mus musculus important protein for normal muscle function. Mutations in the c3 gene result in limb-girdle muscular dystrophy type 2A ?
-
 ?
additional information Rattus norvegicus important protein for normal muscle function. Mutations in the c3 gene result in limb-girdle muscular dystrophy type 2A ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
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 Mus musculus
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skeletal muscle
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
filamin C + H2O enzyme specifically cleaves the C-terminal portion Mus musculus ?
-
 ?
filamin C + H2O enzyme specifically cleaves the C-terminal portion Rattus norvegicus ?
-
 ?
filamin C + H2O enzyme specifically cleaves the C-terminal portion in living cells. Filamin C may be an in vivo substrate to c3, functioning to regulate protein-protein interactions with the sarcoglycans Mus musculus ?
-
 ?
filamin C + H2O enzyme specifically cleaves the C-terminal portion in living cells. Filamin C may be an in vivo substrate to c3, functioning to regulate protein-protein interactions with the sarcoglycans Rattus norvegicus ?
-
 ?
additional information important protein for normal muscle function. Mutations in the c3 gene result in limb-girdle muscular dystrophy type 2A Mus musculus ?
-
 ?
additional information important protein for normal muscle function. Mutations in the c3 gene result in limb-girdle muscular dystrophy type 2A Rattus norvegicus ?
-
 ?