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Literature summary for 3.4.22.53 extracted from

  • Svensson, L.; McDowall, A.; Giles, K.M.; Stanley, P.; Feske, S.; Hogg, N.
    Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes (2010), PLoS ONE, 5, e15090.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
calpeptin
-
Homo sapiens
PD150606
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HSB-2 cell
-
Homo sapiens
-
T-lymphocyte active calpain 2 is concentrated in the trailing edge of the migrating T cell Homo sapiens
-

Synonyms

Synonyms Comment Organism
calpain 2
-
Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of calpain 2 inhibits T cell migration at both the level of single cell tracking and general cell speed Homo sapiens
physiological function calpain 2 controls turnover of lymphocyte function-associated antigen-1 adhesions on migrating T lymphocytes Homo sapiens