Application | Comment | Organism |
---|---|---|
medicine | m-calpain inhibition at the time of reperfusion is a potentially useful strategy to limit infarct size | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpastatin | - |
Rattus norvegicus | |
MDL-28170 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
membrane | in isolated rat hearts, ischemia induces a time-dependent translocation of m-calpain to the membrane that is not associated with calpain activation | Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ induces calpain translocation to the membrane during ischemia | Rattus norvegicus | |
Ca2+ | Ca2+-induced calpain translocation to the membrane during ischemia is independent of its activation | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-fodrin + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
m-calpain | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin | up |
Rattus norvegicus | m-calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin | up |
General Information | Comment | Organism |
---|---|---|
physiological function | m-calpain translocates during ischemia and activates at reperfusion in isolated rat hearts | Rattus norvegicus |