Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.53 extracted from

  • Hernando, V.; Inserte, J.; Sartorio, C.L.; Parra, V.M.; Poncelas-Nozal, M.; Garcia-Dorado, D.
    Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion (2010), J. Mol. Cell. Cardiol., 49, 271-279.
    View publication on PubMed

Application

Application Comment Organism
medicine m-calpain inhibition at the time of reperfusion is a potentially useful strategy to limit infarct size Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
calpastatin
-
Rattus norvegicus
MDL-28170
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-
membrane in isolated rat hearts, ischemia induces a time-dependent translocation of m-calpain to the membrane that is not associated with calpain activation Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ induces calpain translocation to the membrane during ischemia Rattus norvegicus
Ca2+ Ca2+-induced calpain translocation to the membrane during ischemia is independent of its activation Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-fodrin + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
m-calpain
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin up
Rattus norvegicus m-calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin up

General Information

General Information Comment Organism
physiological function m-calpain translocates during ischemia and activates at reperfusion in isolated rat hearts Rattus norvegicus