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Literature summary for 3.4.22.53 extracted from
- Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis (2009), Cancer Res., 69, 3755-3763.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpastatin | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| NB7 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | caspase-8 associates with calpain-2 | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain 2 | - |
Homo sapiens |
| CPN2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in vivo knockdown of calpain2 disrupts metastasis among apoptosis-resistant tumors | Homo sapiens |
| physiological function | calpain-2 is crucial for promotion of migration and metastasis by caspase-8 | Homo sapiens |
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Release 2023.1 (January 2023)
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