Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpastatin | endogenous inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
mitochondrion | m-calpain is present in the intermembrane space of the mitochondria | Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
1 * 80000 + 1 * 30000 | Rattus norvegicus |
80000 | - |
1 * 80000 + 1 * 30000 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | ERp75 plays important role in the refolding of mitochondrial m-calpain large subunit, cytosolic m-calpain does not associate with ERp57 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ERp75 plays important role in the refolding of mitochondrial m-calpain large subunit, cytosolic m-calpain does not associate with ERp57 | Rattus norvegicus | ? | - |
? | |
voltage dependent anion channel + H2O | - |
Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 80000 + 1 * 30000 | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
calpain 2 | - |
Rattus norvegicus |
m-calpain | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | mitochondrial m-calpain is associated with ERp75 and plays an important role in releasing of truncated apoptosis-inducing factor from mitochondria | Rattus norvegicus |