Literature summary for 3.4.22.53 extracted from

Strobl S.; Fernandez-Catalan C.; Braun M.; Huber R.; Masumoto H.; Nakagawa K.; Irie A.; Sorimachi H.; Bourenkow G.; Bartunik H.; Suzuki K.; Bode W.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium (2000), Proc. Natl. Acad. Sci. USA, 97, 588-592.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
full-length human m-calpain containing an N-terminal Gly-Arg-Arg-Asp-Arg-Ser L-chain elongation overexpressed in a baculovirus expression system. Crystals grown by vapor diffusion. The 2.3 A crystal structure of full length heterodimeric m-calpain crystallized in the absence of calcium reveals an oval disc-like shape, with the papain-like catalytic domain dII and the two calmodulin, like domains dIV+dVI occupying opposite poles, and the tumor necrosis factor alpha-like beta-sandwich domain dIII and the N-terminal segments dI+dV located between	Homo sapiens

Crystallization (Comment)

Organism

full-length human m-calpain containing an N-terminal Gly-Arg-Arg-Asp-Arg-Ser L-chain elongation overexpressed in a baculovirus expression system. Crystals grown by vapor diffusion. The 2.3 A crystal structure of full length heterodimeric m-calpain crystallized in the absence of calcium reveals an oval disc-like shape, with the papain-like catalytic domain dII and the two calmodulin, like domains dIV+dVI occupying opposite poles, and the tumor necrosis factor alpha-like beta-sandwich domain dIII and the N-terminal segments dI+dV located between

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme is involved in cytoskeleton remodelling and signal transduction	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P17655	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme is involved in cytoskeleton remodelling and signal transduction	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)