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Literature summary for 3.4.22.52 extracted from

  • Zheng, D.; Wang, G.; Li, S.; Fan, G.C.; Peng, T.
    Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation (2015), Biochim. Biophys. Acta, 1852, 882-892.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
calpain inhibitor-III completely inhibited by 0.01 mM Mus musculus
calpain inhibitor-III completely inhibited by 0.01 mM Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
x * 75000, active fragment, SDS-PAGE Mus musculus
75000
-
x * 75000, active fragment, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-spectrin + H2O Mus musculus
-
?
-
?
alpha-spectrin + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
Mus musculus
-
H9c2 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-spectrin + H2O
-
Mus musculus ?
-
?
alpha-spectrin + H2O
-
Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
? x * 75000, active fragment, SDS-PAGE Mus musculus
? x * 75000, active fragment, SDS-PAGE Rattus norvegicus

Expression

Organism Comment Expression
Mus musculus cell infection with Ad-capn1 and significantly elevates the protein level of calpain-1 up
Rattus norvegicus cell infection with Ad-capn1 and significantly elevates the protein level of calpain-1 up

General Information

General Information Comment Organism
physiological function calpain-1 induces endoplasmic reticulum stress and c-Jun N-terminal protein kinase1/2 activation, thereby mediating apoptosis in cardiomyocytes following hypoxia/reoxygenation. Up-regulation of calpain-1 induces increases in caspase-3 activation and DNA fragmentation, indicative of apoptosis Mus musculus
physiological function calpain-1 induces endoplasmic reticulum stress and c-Jun N-terminal protein kinase1/2 activation, thereby mediating apoptosis in cardiomyocytes following hypoxia/reoxygenation. Up-regulation of calpain-1 induces increases in caspase-3 activation and DNA fragmentation, indicative of apoptosis Rattus norvegicus