Application | Comment | Organism |
---|---|---|
medicine | calpain1 is a therapeutic target in HER2-positive breast cancer | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H272A | catalytically inactive | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpeptin | - |
Homo sapiens | |
MDL28170 | potent inhibitor of the active site of calpain1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
BT-474 cell | - |
Homo sapiens | - |
SK-BR-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human epithelial growth factor receptor 2 + H2O | overexpression of calpain1 or activation of endogenous calpain during adhesion or trastuzumab treatment of trastuzumab-sensitive cells induces cleavage of cytoplasmic domains of human epithelial growth factor receptor 2/phospho-human epithelial growth factor receptor 2 protein | Homo sapiens | 75000 Da fragment + 42000 Da fragment | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calpain1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | calpain regulates trastuzumab sensitivity and survival, and the deregulation of the activation of calpain promotes trastuzumab resistance, trastuzumab-resistant cells require calpain activity for survival and activation of AKT1 | Homo sapiens |