Application | Comment | Organism |
---|---|---|
medicine | calpain-1 activation is important in the development of diabetic cardiomyopathy and thus represents a potential therapeutic target for diabetic heart diseases | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpain inhibitor-III | - |
Rattus norvegicus | |
calpastatin | - |
Rattus norvegicus | |
PD150606 | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | N-succinyl-LLVY + 7-amino-4-methylcoumarin | - |
? |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | high glucose (33 mM) induces calpain-1 activation in cardiomyocytes. Gp91phox-NADPH oxidase contributes to calpain-1 activation in high glucose-induced cardiomyocytes | up |
General Information | Comment | Organism |
---|---|---|
physiological function | calpain-1 activation induces apoptosis through down-regulation of the Na+/K+ ATPase activity in high glucose-stimulated cardiomyocytes and in vivo hyperglycaemic hearts. High glucose-induced calpain-1 activation is mediated through the NADPH oxidase-dependent pathway and associated with activation of L-type calcium channels and ryanodine receptors | Rattus norvegicus |