Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | FANCA and FANCG proteins bind directly to mu-calpain, this binding may lead to inhibition of mu-calpain activity in normal cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alphaII-spectrin + H2O | Homo sapiens | Fanconi anemia proteins play an important role in maintaining the stability of alphaII-spectrin in the cell by regulating its cleavage by mu-calpain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Fanconi anemia disease specific cell type | - |
Homo sapiens | - |
Fanconi anemia lymphoid cell line | - |
Homo sapiens | - |
Fanconi anemia-A cell | - |
Homo sapiens | - |
Fanconi anemia-C cell | - |
Homo sapiens | - |
Fanconi anemia-D2 cell | - |
Homo sapiens | - |
Fanconi anemia-F cell | - |
Homo sapiens | - |
Fanconi anemia-G cell | - |
Homo sapiens | - |
GM-3299 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alphaII-spectrin + H2O | Fanconi anemia proteins play an important role in maintaining the stability of alphaII-spectrin in the cell by regulating its cleavage by mu-calpain | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calpain 1 | - |
Homo sapiens |
micro-calpain | - |
Homo sapiens |
mu-calpain | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | calpain 1 activity is increased 2.5fold in FA-A, FA-D2, and FA-F cells as compared to normal cells and 3.5fold in FA-C and FA-G cells compared to normal cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knocking down mu-calpain by siRNA in FA-A cells restores levels of alphaII-spectrin to normal and reverses a number of the cellular deficiencies in these cells. siRNA knockdown of mu-Calpain in FA-A cells leads to increased cell viability and formation of nuclear foci after damage with a DNA interstrand cross-linking agent | Homo sapiens |