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Literature summary for 3.4.22.52 extracted from

  • Zhang, P.; Sridharan, D.M.; Lambert, M.W.
    Knockdown of micro-calpain in Fanconi Anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair (2010), Biochemistry, 49, 5570-5581.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information FANCA and FANCG proteins bind directly to mu-calpain, this binding may lead to inhibition of mu-calpain activity in normal cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alphaII-spectrin + H2O Homo sapiens Fanconi anemia proteins play an important role in maintaining the stability of alphaII-spectrin in the cell by regulating its cleavage by mu-calpain ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Fanconi anemia disease specific cell type
-
Homo sapiens
-
Fanconi anemia lymphoid cell line
-
Homo sapiens
-
Fanconi anemia-A cell
-
Homo sapiens
-
Fanconi anemia-C cell
-
Homo sapiens
-
Fanconi anemia-D2 cell
-
Homo sapiens
-
Fanconi anemia-F cell
-
Homo sapiens
-
Fanconi anemia-G cell
-
Homo sapiens
-
GM-3299 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alphaII-spectrin + H2O Fanconi anemia proteins play an important role in maintaining the stability of alphaII-spectrin in the cell by regulating its cleavage by mu-calpain Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
calpain 1
-
Homo sapiens
micro-calpain
-
Homo sapiens
mu-calpain
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens calpain 1 activity is increased 2.5fold in FA-A, FA-D2, and FA-F cells as compared to normal cells and 3.5fold in FA-C and FA-G cells compared to normal cells up

General Information

General Information Comment Organism
malfunction knocking down mu-calpain by siRNA in FA-A cells restores levels of alphaII-spectrin to normal and reverses a number of the cellular deficiencies in these cells. siRNA knockdown of mu-Calpain in FA-A cells leads to increased cell viability and formation of nuclear foci after damage with a DNA interstrand cross-linking agent Homo sapiens