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Literature summary for 3.4.22.52 extracted from
- Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction (2010), Am. J. Respir. Cell Mol. Biol., 42, 80-87.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| endotoxin | treatment with 12 mg/kg endotoxin increases diaphragm calpain activity and active calpain I protein | Mus musculus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | calpain inhibition attenuates endotoxin-induced diaphragm weakness, suggesting that such inhibitors may be a potential treatment to improve respiratory function in infected patients | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpain inhibitor peptide III | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| talin + H2O | Mus musculus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| diaphragm | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| talin + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain I | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | treatment with 12 mg/kg endotoxin increases active calpain I protein | up |
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Release 2023.1 (January 2023)
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