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BRENDA support

Literature summary for 3.4.22.52 extracted from

  • Wan, W.; DePetrillo, P.B.
    Ritonavir inhibition of calcium-activated neutral proteases (2002), Biochem. Pharmacol., 63, 1481-1484.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ritonavir also inhibits calcium-stimulated calpain activity in PC12 cells in situ. Ritonavir or analogues of the drug should by investigated as cytoprotective agents in conditions where cell death or injury is mediated via calpain activation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme mediates tissue injury following post-ischemic and post-traumatic stress ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme mediates tissue injury following post-ischemic and post-traumatic stress Rattus norvegicus ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0059
-
ritonavir
-
Rattus norvegicus