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Literature summary for 3.4.22.52 extracted from

  • Shields, D.C.; Schaecher, K.E.; Saido, T.C.; Banik, N.L.
    A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain (1999), Proc. Natl. Acad. Sci. USA, 96, 11486-11491.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens translational expression of mu-calpain is up-regulated by 462.5% in MW white matter compared with controls. mu-Calpain activity and translational expression are not increased significantly in white matter from patients with Parkinson‘s or Alzheimer diseases compared with that of normal controls. Because calpain degrades all major myelin proteins, the increased activity and expression of this proteinase may play a critical role in myelinolysis in MS ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain white matter from patients with MS and Parkinson‘s and Alzheimer‘s diseases and white matter from normal control Homo sapiens
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cerebral white matter
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-subunit of fodrin + H2O
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Homo sapiens 150000 Da fragment + ?
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?
additional information translational expression of mu-calpain is up-regulated by 462.5% in MW white matter compared with controls. mu-Calpain activity and translational expression are not increased significantly in white matter from patients with Parkinson‘s or Alzheimer diseases compared with that of normal controls. Because calpain degrades all major myelin proteins, the increased activity and expression of this proteinase may play a critical role in myelinolysis in MS Homo sapiens ?
-
?