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Literature summary for 3.4.22.51 extracted from

  • Abdulla, M.H.; OBrien, T.; Mackey, Z.B.; Sajid, M.; Grab, D.J.; McKerrow, J.H.
    RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model (2008), PLoS Negl. Trop. Dis., 2, e298.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.51

Application

Application Comment Organism
pharmacology induction of RNAi against brucipain of Trypanosoma brucei does not cure mice from infection, however, 50% of these mice survive 60 days longer than uninduced controls. The ability of Trypanosoma brucei to cross an in vitro model of the human blood-brain barrier is also reduced by brucipain RNAi induction Trypanosoma brucei

Protein Variants

Protein Variants Comment Organism
additional information induction of RNAi against brucipain of Trypanosoma brucei does not cure mice from infection, however, 50% of these mice survive 60 days longer than uninduced controls. The ability of Trypanosoma brucei to cross an in vitro model of the human blood-brain barrier is also reduced by brucipain RNAi induction Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei enzyme may be involved in facilitating parasite entry into the brain ?
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 ?
additional information Trypanosoma brucei 90-13 enzyme may be involved in facilitating parasite entry into the brain ?
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 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme may be involved in facilitating parasite entry into the brain Trypanosoma brucei ?
-
 ?
additional information enzyme may be involved in facilitating parasite entry into the brain Trypanosoma brucei 90-13 ?
-
 ?

Synonyms

Synonyms Comment Organism
brucipain
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 Trypanosoma brucei