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Literature summary for 3.4.22.51 extracted from

  • Romeiro, N.C.; Aguirre, G.; Hernandez, P.; Gonzalez, M.; Cerecetto, H.; Aldana, I.; Perez-Silanes, S.; Monge, A.; Barreiro, E.J.; Lima, L.M.
    Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates (2009), Bioorg. Med. Chem., 17, 641-652.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
(E/Z)-N'-(2-chlorobenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(2-hhenylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(2-hydroxybenzylidene)-3-methylquinoxaline-2-hydrazide 25 microM Trypanosoma cruzi
(E/Z)-N'-(2-hydroxybenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM Trypanosoma cruzi
(E/Z)-N'-(3-chlorobenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(4-bromobenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(4-chlorobenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(4-dimethylaminobenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(4-fluorobenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(4-hydroxybenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(4-isopropylbenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(4-nitrobenzylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(furfurylidene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(pyridin-2-ylmethylene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-(pyridin-4-ylmethylene)-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
(E/Z)-N'-benzylidene-3-phenylquinoxaline-2-hydrazide 25 microM, inhibition of parasite growth Trypanosoma cruzi
nifurtimox 25 microM Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-
Trypanosoma cruzi Tulahuen 2
-
-
-

Synonyms

Synonyms Comment Organism
cruzain
-
Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0077
-
-
Trypanosoma cruzi nifurtimox
0.0159
-
-
Trypanosoma cruzi (E/Z)-N'-(2-hydroxybenzylidene)-3-phenylquinoxaline-2-hydrazide
0.02
-
-
Trypanosoma cruzi (E/Z)-N'-(2-hydroxybenzylidene)-3-methylquinoxaline-2-hydrazide