Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli strain DH5alpha | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(N-1-phenyl-ethylidenehydrazino)-4-trifluoromethylpyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-1-phenyl-ethylidenehydrazino)-5-methyl-4-trifluoro-methyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-1-phenyl-ethylidenehydrazino)-6-methyl-4-trifluoro-methyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-2-hydroxy-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-2-hydroxy-benzylidenehydrazino)-5-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-2-hydroxy-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-2-methoxy-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-2-methoxy-benzylidenehydrazino)-5-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-2-methoxy-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyrimidine | 100 microM, 20% inhibitory effect | Trypanosoma cruzi | |
2-(N-2-methyl-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | 100 microM, 45% inhibitory effect | Trypanosoma cruzi | |
2-(N-2-methyl-benzylidenehydrazino)-5-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-2-methyl-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyrimidine | 100 microM, 45% inhibitory effect | Trypanosoma cruzi | |
2-(N-4-chloro-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | 100 microM, 80% inhibitory effect | Trypanosoma cruzi | |
2-(N-4-chloro-benzylidenehydrazino)-5-methyl-4-trifluoro-methyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-4-chloro-benzylidenehydrazino)-6-methyl-4-trifluoro-methyl-pyrimidine | 100 microM, 60% inhibitory effect | Trypanosoma cruzi | |
2-(N-4-methoxy-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | 100 microM, 40% inhibitory effect | Trypanosoma cruzi | |
2-(N-4-methoxy-benzylidenehydrazino)-5-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-4-methoxy-benzylidenehydrazino)-6-methyl-4-trifluoro-methyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-4-methyl-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | 100 microM, 40% inhibitory effect | Trypanosoma cruzi | |
2-(N-4-methyl-benzylidenehydrazino)-5-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-4-methyl-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-4-nitro-benzylidenehydrazino)-4-trifluoromethylpyrimidine | 100 microM, 50% inhibitory effect | Trypanosoma cruzi | |
2-(N-4-nitro-benzylidenehydrazino)-5-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-4-nitro-benzylidenehydrazino)-6-methyl-4-trifluoro-methyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-benzylidenehydrazino)-4-trifluoromethylpyrimidine | 100 microM, 30% inhibitory effect | Trypanosoma cruzi | |
2-(N-benzylidenehydrazino)-5-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
2-(N-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyrimidine | 100 microM | Trypanosoma cruzi | |
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | irreversible inhibitor | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
cruzain | - |
Trypanosoma cruzi |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
assay at room temperature, pH 6.5, 5 min, 0.64 nM cruzain, 50 mM sodium phosphate, 100 mM sodium chloride, 5 mM EDTA | Trypanosoma cruzi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at room temperature, 5 min, 0.64 nM cruzain, 50 mM sodium phosphate, 100 mM sodium chloride, 5 mM EDTA | Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.085 | - |
- |
Trypanosoma cruzi | 2-(N-4-chloro-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | |
0.1 | - |
about 0.1 mM | Trypanosoma cruzi | 2-(N-4-nitro-benzylidenehydrazino)-4-trifluoromethylpyrimidine | |
0.1 | - |
about 0.1 mM | Trypanosoma cruzi | 2-(N-4-chloro-benzylidenehydrazino)-6-methyl-4-trifluoro-methyl-pyrimidine | |
0.1 | - |
above 0.1 mM | Trypanosoma cruzi | 2-(N-2-methyl-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | |
0.1 | - |
above 0.1 mM | Trypanosoma cruzi | 2-(N-4-methyl-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | |
0.1 | - |
above 0.1 mM | Trypanosoma cruzi | 2-(N-4-methoxy-benzylidenehydrazino)-4-trifluoromethyl-pyrimidine | |
0.1 | - |
above 0.1 mM | Trypanosoma cruzi | 2-(N-2-methyl-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyrimidine | |
0.15 | - |
above 0.15 mM | Trypanosoma cruzi | 2-(N-benzylidenehydrazino)-4-trifluoromethylpyrimidine | |
0.15 | - |
above 0.15 mM | Trypanosoma cruzi | 2-(N-2-methoxy-benzylidenehydrazino)-6-methyl-4-trifluoromethyl-pyrimidine |