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Literature summary for 3.4.22.51 extracted from
- Cruzipain and SP600125 induce p38 activation, alter NO/arginase balance and favor the survival of Trypanosoma cruzi in macrophages (2008), Acta Trop., 106, 119-127.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | in this study it is shown in murine macrophage cell line J774 as well as in murine bone marrow-derived macrophages, that cruzipain induces p38 phosphorylation with Trypanosoma cruzi infection triggering mainly JNK and ERK phosphorylation. Cruzipain also favors the survival in macrophages by changing the iNOS/arginase balance | Trypanosoma cruzi |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | studies are carried out using murine macrophage cell line J774 as well as bone marrow-derived macrophages from BALB/c mice | Trypanosoma cruzi | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cruzipain | - |
Trypanosoma cruzi |
| cz | - |
Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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