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Literature summary for 3.4.22.51 extracted from

  • Chiyanzu, I.; Hansell, E.; Gut, J.; Rosenthal, P.J.; McKerrow, J.H.; Chibale, K.
    Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain (2003), Bioorg. Med. Chem. Lett., 13, 3527-3530.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3Z)-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.008 mM Trypanosoma cruzi
(3Z)-5,7-dimethyl-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.016 mM Trypanosoma cruzi
(3Z)-5-bromo-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.02 mM Trypanosoma cruzi
(3Z)-5-chloro-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.021 mM Trypanosoma cruzi
(3Z)-5-chloro-7-methyl-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.0105 mM Trypanosoma cruzi
(3Z)-5-iodo-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.009 mM Trypanosoma cruzi
(3Z)-5-methyl-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.02-0.05 mM Trypanosoma cruzi
(3Z)-5-nitro-1H-indole-2,3-dione 3-thiosemicarbazone IC50: 0.03 mM Trypanosoma cruzi
1-(2,5-dimethylbenzyl)-5-methyl-1H-indole-2,3-dione IC50: 0.08 mM Trypanosoma cruzi
1-(3-methoxybenzyl)-5-methyl-1H-indole-2,3-dione IC50: 0.002 mM Trypanosoma cruzi
1-(biphenyl-2-ylmethyl)-5-methyl-1H-indole-2,3-dione IC50: 0.0028 mM Trypanosoma cruzi
1-benzyl-5-chloro-1H-indole-2,3-dione IC50: 0.09 mM Trypanosoma cruzi
1-benzyl-5-iodo-1H-indole-2,3-dione IC50: 0.09 mM Trypanosoma cruzi
5-chloro-1-(4-chlorobenzyl)-1H-indole-2,3-dione IC50: 0.006 mM Trypanosoma cruzi
5-fluoro-1H-indole-2,3-dione IC50: 0.03 mM Trypanosoma cruzi
benzyl 5-chloro-2,3-dioxoindoline-1-carboxylate IC50: 0.08 mM Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
IC50: 0.002 mM Trypanosoma cruzi 1-(3-methoxybenzyl)-5-methyl-1H-indole-2,3-dione
0.0028
-
IC50: 0.0028 mM Trypanosoma cruzi 1-(biphenyl-2-ylmethyl)-5-methyl-1H-indole-2,3-dione
0.006
-
IC50: 0.006 mM Trypanosoma cruzi 5-chloro-1-(4-chlorobenzyl)-1H-indole-2,3-dione
0.008
-
IC50: 0.008 mM Trypanosoma cruzi (3Z)-1H-indole-2,3-dione 3-thiosemicarbazone
0.009
-
IC50: 0.009 mM Trypanosoma cruzi (3Z)-5-iodo-1H-indole-2,3-dione 3-thiosemicarbazone
0.0105
-
IC50: 0.0105 mM Trypanosoma cruzi (3Z)-5-chloro-7-methyl-1H-indole-2,3-dione 3-thiosemicarbazone
0.016
-
IC50: 0.016 mM Trypanosoma cruzi (3Z)-5,7-dimethyl-1H-indole-2,3-dione 3-thiosemicarbazone
0.02
-
IC50: 0.02 mM Trypanosoma cruzi (3Z)-5-bromo-1H-indole-2,3-dione 3-thiosemicarbazone
0.02 0.05 IC50: 0.02-0.05 mM Trypanosoma cruzi (3Z)-5-methyl-1H-indole-2,3-dione 3-thiosemicarbazone
0.021
-
IC50: 0.021 mM Trypanosoma cruzi (3Z)-5-chloro-1H-indole-2,3-dione 3-thiosemicarbazone
0.03
-
IC50: 0.03 mM Trypanosoma cruzi 5-fluoro-1H-indole-2,3-dione
0.03
-
IC50: 0.03 mM Trypanosoma cruzi (3Z)-5-nitro-1H-indole-2,3-dione 3-thiosemicarbazone
0.08
-
IC50: 0.08 mM Trypanosoma cruzi 1-(2,5-dimethylbenzyl)-5-methyl-1H-indole-2,3-dione
0.08
-
IC50: 0.08 mM Trypanosoma cruzi benzyl 5-chloro-2,3-dioxoindoline-1-carboxylate
0.09
-
IC50: 0.09 mM Trypanosoma cruzi 1-benzyl-5-chloro-1H-indole-2,3-dione
0.09
-
IC50: 0.09 mM Trypanosoma cruzi 1-benzyl-5-iodo-1H-indole-2,3-dione