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Literature summary for 3.4.22.51 extracted from
- Congopain from Trypanosoma congolense: drug target and vaccine candidate (2002), Biol. Chem., 383, 739-749.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | activates | Trypanosoma congolense |  |
| dithiothreitol | activates | Trypanosoma congolense | |
| L-cysteine | activates | Trypanosoma congolense | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-trans-epoxysuccinylleucylamido(4-guanidino)butane | - |
Trypanosoma congolense | |
| leupeptin | - |
Trypanosoma congolense | |
| additional information | pro-region of the trypanosomal enzyme inhibits the enzyme function, cystatins and kininogens are inhibitors, overview: inhibitors | Trypanosoma congolense |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
SDS-PAGE | Trypanosoma congolense |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma congolense | Q26909 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Trypanosoma congolense |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Trypanosoma congolense | ? | - |
? | |
| additional information | no substrate: benzyloxycarbonyl-Arg-Arg-aminomethyl coumarin | Trypanosoma congolense | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Trypanosoma congolense |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 8.5 | - |
Trypanosoma congolense |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
stable at alkaline and acid pH | Trypanosoma congolense |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki for cystatins and kininogens in the picomolar range | Trypanosoma congolense |
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