Inhibitors | Comment | Organism | Structure |
---|---|---|---|
securin | - |
Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
200000 | - |
x * 200000, GFP-tagged enzyme, SDS-PAGE | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | Saccharomyces cerevisiae | - |
? | - |
? | |
additional information | Saccharomyces cerevisiae | the enzyme interacts with Ty1-IN and does not affect the processing of the TyA-TyB polypeptide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | Q03018 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
additional information | the enzyme interacts with Ty1-IN and does not affect the processing of the TyA-TyB polypeptide | Saccharomyces cerevisiae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 200000, GFP-tagged enzyme, SDS-PAGE | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Esp1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | separase is required at the onset of anaphase to cleave cohesin and thereby enable sister chromatid separation. The enzyme also promotes release of the Cdc14 phosphatase from the nucleolus to enable mitotic exit. The enzyme serves two roles to mediate Ty1 transposition, one to remove cohesin and the second to target Ty1-IN to chromatin | Saccharomyces cerevisiae |