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Literature summary for 3.4.22.49 extracted from

  • Ho, K.L.; Ma, L.; Cheung, S.; Manhas, S.; Fang, N.; Wang, K.; Young, B.; Loewen, C.; Mayor, T.; Measday, V.
    A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition (2015), PLoS Genet., 11, e1005109.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
securin
-
Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000
-
x * 200000, GFP-tagged enzyme, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Saccharomyces cerevisiae
-
?
-
?
additional information Saccharomyces cerevisiae the enzyme interacts with Ty1-IN and does not affect the processing of the TyA-TyB polypeptide ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q03018
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O
-
Saccharomyces cerevisiae ?
-
?
additional information the enzyme interacts with Ty1-IN and does not affect the processing of the TyA-TyB polypeptide Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
? x * 200000, GFP-tagged enzyme, SDS-PAGE Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Esp1
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function separase is required at the onset of anaphase to cleave cohesin and thereby enable sister chromatid separation. The enzyme also promotes release of the Cdc14 phosphatase from the nucleolus to enable mitotic exit. The enzyme serves two roles to mediate Ty1 transposition, one to remove cohesin and the second to target Ty1-IN to chromatin Saccharomyces cerevisiae