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Literature summary for 3.4.22.49 extracted from
- Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation (2012), Dev. Cell, 23, 124-136.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cohesin + H2O | Saccharomyces cerevisiae | cohesin Is cleaved with similar kinetics and timing near the centromere and telomere. Separase inhibition of PP2ACdc55 is necessary for robust cleavage of cohesin | ? | - |
? |  |
| Scc1 + H2O | Saccharomyces cerevisiae | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | Q03018 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cohesin + H2O | cohesin Is cleaved with similar kinetics and timing near the centromere and telomere. Separase inhibition of PP2ACdc55 is necessary for robust cleavage of cohesin | Saccharomyces cerevisiae | ? | - |
? | |
| Scc1 + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | separase acts directly on Scc1 and also indirectly, through inhibition of PP2ACdc55, to stimulate cohesin cleavage, providing a feedforward loop that may contribute to a robust and timely anaphase. PP2A activity is inhibited by separase during anaphase, triggering activation of the Cdc14 mitotic phosphatase | Saccharomyces cerevisiae |
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