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Literature summary for 3.4.22.49 extracted from

  • Yang, X.; Boateng, K.A.; Strittmatter, L.; Burgess, R.; Makaroff, C.A.
    Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis (2009), Plant Physiol., 151, 323-333.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Arabidopsis thaliana
-
 cleaved cohesin
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
meiotic cell
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O
-
 Arabidopsis thaliana cleaved cohesin
-
 ?

Synonyms

Synonyms Comment Organism
ESP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction meiotic expression of ESP RNA interference blocks the removal of cohesin during both meiosis I and II, results in alterations in nonhomologous centromere association, disrupts the radial microtubule system after telophase II, and affects the proper establishment of nuclear cytoplasmic domains, resulting in the formation of multinucleate microspores Arabidopsis thaliana
physiological function Separase is essential for sister chromatid separation during anaphase II. Separase-mediated proteolytic cleavage of the alpha-kleisin subunit of the cohesin complex at the metaphase-to-anaphase transition is essential for the proper segregation of chromosomes. Separase is also involved in mitotic and meiotic anaphase spindle assembly and elongation, interphase spindle pole body positioning, and epithelial cell reorganization Arabidopsis thaliana