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Literature summary for 3.4.22.49 extracted from
- Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement (2009), J. Cell Biol., 187, 607-614.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Scc1 + H2O | Homo sapiens | Scc1 is a subunit of cohesion, centrosomal Scc1 is cleaved by separase coincidentally with chromatin Scc1 | fragments of Scc1 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Scc1 + H2O | Scc1 is a subunit of cohesion, centrosomal Scc1 is cleaved by separase coincidentally with chromatin Scc1 | Homo sapiens | fragments of Scc1 | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | sister chromatid separation at anaphase is triggered by cleavage of the cohesin subunit Scc1, which is mediated by separase | Homo sapiens |
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