Literature summary for 3.4.22.49 extracted from

Huang, X.; Andreu-Vieyra, C.V.; Wang, M.; Cooney, A.J.; Matzuk, M.M.; Zhang, P.
Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation (2009), Mol. Cell. Biol., 29, 1498-1505.

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Protein Variants

Protein Variants	Comment	Organism
S1121A	mutation causes embryogenesis failure between the 8- and 16-cell stages in mice	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
securin	activity inhibited prior to the onset of the anaphase	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation on Ser1121, mechanism to inhibit activity prior to the onset of the anaphase. Inhibitory phosphorylation of separase is not required for meiosis. Critical role of separase phosphorylation in germ cell development as well as in early embryogenesis	Mus musculus

Synonyms

Synonyms	Comment	Organism
separase	-	Mus musculus

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Release 2023.1 (January 2023)