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Literature summary for 3.4.22.49 extracted from

  • Nagao, K.; Yanagida, M.
    Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase (2006), Genes Cells, 11, 247-260.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
securin the central domain of securin has a functionally essential specific sequence that may directly interact with the catalytic region of separase. This central securin domain is unrelated to destruction by polyubiquitination, but essential for the activation of separase Schizosaccharomyces pombe

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
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