Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.49 extracted from

  • Chestukhin, A.; Pfeffer, C.; Milligan, S.; DeCaprio, J.A.; Pellman, D.
    Processing, localization, and requirement of human separase for normal anaphase progression (2003), Proc. Natl. Acad. Sci. USA, 100, 4574-4579.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and C2029 mutant enzyme in 293 EcR and HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C2029A
-
Homo sapiens
E1483R/R1486E autoproteolytically cleaved like wild-type Homo sapiens
E1503R/R1506E autoproteolytically cleaved like wild-type Homo sapiens
E1532R/R1535E autoproteolytically cleaved like wild-type Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome localized in centrosomes before anaphase Homo sapiens 5813
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
225000
-
recombinant separase, immunoblotting Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-