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Literature summary for 3.4.22.47 extracted from

  • Smalley, J.W.; Thomas, M.F.; Birss, A.J.; Withnall, R.; Silver, J.
    A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin (2004), Biochem. J., 379, 833-840.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.47

Protein Variants

Protein Variants Comment Organism
additional information strain K1A is Kgp-deficient Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
leupeptin inhibits Arg-specific Rgp, but not Lys-specific Kgp Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis a combination of both arginine- and lysine-specific gingipain activity is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin, interaction with oxyhemoglobin, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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 gene kgp, wild-type strain W50, Kgp-deficient strain K1A
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a combination of both arginine- and lysine-specific gingipain activity is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin, interaction with oxyhemoglobin, overview Porphyromonas gingivalis ?
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 ?
N-alpha-acetyl-L-lysine-4-nitroanilide + H2O
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 Porphyromonas gingivalis N-alpha-acetyl-L-lysine + 4-nitroaniline
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 ?

Synonyms

Synonyms Comment Organism
KGP
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 Porphyromonas gingivalis
lysine-specific gingipain
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 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Porphyromonas gingivalis