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Literature summary for 3.4.22.46 extracted from
- Substrate specificity of the secreted nisin leader peptidase NisP (2017), Biochemistry, 56, 4005-4014 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Lactococcus lactis subsp. lactis | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nisin-(leader peptide) + H2O | Lactococcus lactis subsp. lactis | after translocation into the extracellular space, the leader peptide is cleaved by the leader peptidase NisP, resulting in active nisin. NisP recognizes the cleavage site GASPR-/-IT located at the C-terminal end of the leader peptide | nisin + leader peptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactococcus lactis subsp. lactis | Q07596 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Lactococcus lactis subsp. lactis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nisin-(leader peptide) + H2O | - |
Lactococcus lactis subsp. lactis | nisin + leader peptide | - |
? | |
| nisin-(leader peptide) + H2O | after translocation into the extracellular space, the leader peptide is cleaved by the leader peptidase NisP, resulting in active nisin. NisP recognizes the cleavage site GASPR-/-IT located at the C-terminal end of the leader peptide | Lactococcus lactis subsp. lactis | nisin + leader peptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| leader peptidase NisP | - |
Lactococcus lactis subsp. lactis |
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