Literature summary for 3.4.22.46 extracted from

Wang, D.; Fang, L.; Luo, R.; Ye, R.; Fang, Y.; Xie, L.; Chen, H.; Xiao, S.
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels (2010), Biochem. Biophys. Res. Commun., 399, 72-78.

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Cloned(Commentary)

Cloned (Comment)	Organism
PK-15 cells are transfected with a HA-tagged Labpro expression construct, together with a luciferase reporter plasmid with the porcine IFN-alpha1 promoter or the IFN-beta promoter and pRL-TK. At 24 h post-transfection, the cells were further transfected or mock-transfected with poly(I:C) followed by the dual-luciferase assay, quantitative real-time RT-PCR, overview	Foot-and-mouth disease virus

Organism

Organism	UniProt	Comment	Textmining
Foot-and-mouth disease virus	-	FMDV	-

Synonyms

Synonyms	Comment	Organism
Leader proteinase	-	Foot-and-mouth disease virus
Lpro	-	Foot-and-mouth disease virus

General Information

General Information	Comment	Organism
physiological function	the leader proteinase, Lpro, acts as an interferon-beta antagonist and inhibits IFN-alpha1/beta promoter activation, poly(I:C)-induced IFN-alpha1/beta mRNA expression, and dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels. Lpro significantly reduced the transcription of multiple IRF-responsive genes	Foot-and-mouth disease virus

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Release 2023.1 (January 2023)