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Literature summary for 3.4.22.46 extracted from

  • de Los Santos, T.; de Avila Botton, S.; Weiblen, R.; Grubman, M.J.
    The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response (2006), J. Virol., 80, 1906-1914.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information a mutant virus A12-LLV2 lacking the leader proteinase is attenuated in cell culture and susceptible animals due to the inability of the mutant virus to block the expression of type I interferon alpha/beta, the blockade results in the IFN-induced inhibition of FMDV replication, overview Foot-and-mouth disease virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eukaryotic translation initiation factor eIF4GI + H2O Foot-and-mouth disease virus eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis ?
-
 ?
eukaryotic translation initiation factor eIF4GI + H2O Foot-and-mouth disease virus FMDV eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis ?
-
 ?
additional information Foot-and-mouth disease virus the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells ?
-
 ?
additional information Foot-and-mouth disease virus FMDV the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Foot-and-mouth disease virus
-
 FMDV
-
Foot-and-mouth disease virus FMDV
-
 FMDV
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic translation initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis Foot-and-mouth disease virus ?
-
 ?
eukaryotic translation initiation factor eIF4GI + H2O eukaryotic host cell protein substrate Foot-and-mouth disease virus ?
-
 ?
eukaryotic translation initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis Foot-and-mouth disease virus FMDV ?
-
 ?
eukaryotic translation initiation factor eIF4GI + H2O eukaryotic host cell protein substrate Foot-and-mouth disease virus FMDV ?
-
 ?
additional information the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells Foot-and-mouth disease virus ?
-
 ?
additional information the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells Foot-and-mouth disease virus FMDV ?
-
 ?

Synonyms

Synonyms Comment Organism
Leader proteinase
-
 Foot-and-mouth disease virus
Lpro
-
 Foot-and-mouth disease virus