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Literature summary for 3.4.22.45 extracted from
- Potyvirus helper component proteinase (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press, 2, 1262-1264.
No PubMed abstract available
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Tobacco vein mottling potyvirus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Tobacco vein mottling potyvirus | the enzyme is essential for viral infection of plants and acts as post-transcriptional gene silencer by interferring with miRNA-controlled developmental pathways | ? | - |
? | |
| potyvirus helper component + H2O | Tobacco vein mottling potyvirus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Tobacco vein mottling potyvirus | - |
ssRNA positive-strand virus, no DNA stage | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is essential for viral infection of plants and acts as post-transcriptional gene silencer by interferring with miRNA-controlled developmental pathways | Tobacco vein mottling potyvirus | ? | - |
? | |
| additional information | the cleavage site is highly conserved at P4, P2, P1, and P1' positions | Tobacco vein mottling potyvirus | ? | - |
? | |
| potyvirus helper component + H2O | - |
Tobacco vein mottling potyvirus | ? | - |
? | |
| potyvirus helper component + H2O | the enzyme cleaves at the C-terminal Gly-/-Gly bond | Tobacco vein mottling potyvirus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Tobacco vein mottling potyvirus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HC-Pro proteinase | - |
Tobacco vein mottling potyvirus |
| More | the enzyme belongs to the C6 peptidase family | Tobacco vein mottling potyvirus |
| potyvirus helper component proteinase | - |
Tobacco vein mottling potyvirus |
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Release 2023.1 (January 2023)
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