Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.43 extracted from

  • Leng, Y.P.; Ma, Y.S.; Li, X.G.; Chen, R.F.; Zeng, P.Y.; Li, X.H.; Qiu, C.F.; Li, Y.P.; Zhang, Z.; Chen, A.F.
    L-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia (2018), Br. J. Pharmacol., 175, 1157-1172 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.43

Cloned(Commentary)

Cloned (Comment) Organism
gene CTSV, real-time PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide SID, suppresses the activity of cathepsin V and reverses the upregulation of inflammatory cytokines (IL-6, IL-8 and TNF-alpha), adhesion and chemotaxis of leukocytes and vascular inflammation induced by L-homocysteine (L-Hcy) in vivo and in vitro. SID also inhibits the monocyte-endothelial adhesion and neutrophil chemotaxis induced by L-Hcy. SID reverses this increased phosphorylation of ERK1/2 and STAT1, which is similar to the results obtained in vitro Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
nucleus cathepsin V is located on the outside of the nucleus Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O60911
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
HUVEC cell immunohistochemic enzyme analysis Homo sapiens
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens siRNA-cathepsin V inhibits the up-regulation of cathepsin V-induced by L-homocysteine down
Homo sapiens L-homocysteine induces cathepsin V expression, L-homocysteine promoted cathepsin V expression in HUVECs. Methylation of the promoter region of cathepsin V is decreased following L-Hcy stimulation up

General Information

General Information Comment Organism
malfunction increased cathepsin V promoted the degradation of DUSP6 and DUSP7, phosphorylation and subsequent nuclear translocation of ERK1/2, phosphorylation of STAT1 and expression of interleukin (IL)-6, IL-8 and TNF-alpha Homo sapiens
metabolism effects of cathepsin V on the dual-specificity protein phosphatases (DUSPs) and MAPK pathways Homo sapiens
physiological function L-homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Cathepsin V, specifically expressed in humans, is involved in vascular diseases through its elastolytic and collagenolytic activities. Cathepsin V mediates the L-homocysteine-induced upregulation of inflammatory cytokines Homo sapiens