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Literature summary for 3.4.22.43 extracted from

  • Wong, C.H.; Wu, Z.; Yu, Q.
    CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis (2014), Oncogene, 33, 1249-1257.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O60911
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Homo sapiens
-
colorectal cancer cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
RKO cell
-
Homo sapiens
-
SW-620 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
cathepsin L2
-
Homo sapiens
cathepsin like 2
-
Homo sapiens
cathepsin V
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens E2F1 activates cathepsin like 2 gene promoter activity up

General Information

General Information Comment Organism
malfunction RNAi-mediated depletion of the enzyme effectively abrogates ectopic E2F1-induced apoptosis, coupled with reduced lysosomal membrane permeabilization and mitochondrial membrane depolarization. Enzyme knockdown also inhibits apoptosis mediated by the endogenous E2F1 activated by DNA damage. Enzyme depletion in cancer cells results in inhibition of histone deacetylase inhibitor-induced apoptosis Homo sapiens
physiological function cathepsin like 2 is required for E2F1-induced apoptosis by engaging lysosomal membrane permeabilization. Its level also modulates the cellular sensitivity to histone deacetylase inhibitor Homo sapiens