BRENDA - Enzyme Database
show all sequences of 3.4.22.43

Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation

Keegan, P.M.; Wilder, C.L.; Platt, M.O.; Mol. Cell. Biochem. 367, 65-72 (2012)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
x * 35000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Elastin + H2O
Homo sapiens
-
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
O60911
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
aortic endothelial cell
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
Elastin + H2O
-
732502
Homo sapiens
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 35000, SDS-PAGE
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
x * 35000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Elastin + H2O
Homo sapiens
-
?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
aortic endothelial cell
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
Elastin + H2O
-
732502
Homo sapiens
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 35000, SDS-PAGE
Homo sapiens
Expression
Organism
Commentary
Expression
Homo sapiens
tissue necrosis factor alpha increases cathepsin V expression and activity by 2fold. Tissue necrosis factor alpha and co-culturing with THP-1 monocytes stimulates a 460% increase in cathepsin V active enzyme
up
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
tissue necrosis factor alpha increases cathepsin V expression and activity by 2fold. Tissue necrosis factor alpha and co-culturing with THP-1 monocytes stimulates a 460% increase in cathepsin V active enzyme
up
Other publictions for EC 3.4.22.43
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
753977
Mons
The Alkyne moiety as a latent ...
Homo sapiens
J. Am. Chem. Soc.
141
3507-3514
2019
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752678
Homma
Melanosome degradation in epi ...
Homo sapiens
Biochem. Biophys. Res. Commun.
500
339-343
2018
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Leng
L-Homocysteine-induced cathep ...
Homo sapiens
Br. J. Pharmacol.
175
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2018
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1
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1
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2
3
3
2
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753828
Huang
Exogenous cathepsin V protein ...
Homo sapiens
Int. J. Biochem. Cell Biol.
89
6-15
2017
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1
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752418
Naumnik
Endostatin and cathepsin-V in ...
Homo sapiens
Adv. Exp. Med. Biol.
833
55-61
2015
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2
2
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754753
Pribis
The HIV protease inhibitor sa ...
Homo sapiens
Mol. Med.
21
749-757
2015
-
1
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1
-
5
-
1
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1
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4
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2
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2
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1
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2
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2
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1
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1
1
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732591
Wong
CTSL2 is a pro-apoptotic targe ...
Homo sapiens
Oncogene
33
1249-1257
2014
-
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1
2
2
1
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731213
McCarthy
-
Cathepsin L proteases of the p ...
Lepeophtheirus salmonis
Aquaculture
356-357
264-271
2012
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1
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731573
Skrzypczak
Expression of cysteine proteas ...
Homo sapiens
Cancer Invest.
30
398-403
2012
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2
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1
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1
-
-
732049
Funkelstein
Human cathepsin V protease par ...
Homo sapiens
J. Biol. Chem.
287
15232-15241
2012
-
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1
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1
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3
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1
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4
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5
1
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1
1
-
-
-
732502
Keegan
Tumor necrosis factor alpha st ...
Homo sapiens
Mol. Cell. Biochem.
367
65-72
2012
-
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1
1
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1
1
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1
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1
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732867
Novinec
A simple and efficient protoco ...
Homo sapiens
Protein Expr. Purif.
82
1-5
2012
1
-
1
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1
2
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1
1
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2
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1
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1
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1
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1
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4
1
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2
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-
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2
2
717159
Wilder
Manipulating substrate and pH ...
Homo sapiens
Arch. Biochem. Biophys.
516
52-57
2011
-
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1
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1
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2
1
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2
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1
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1
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1
1
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1
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717374
Severino
Acridone alkaloids as potent i ...
Homo sapiens
Bioorg. Med. Chem.
19
1477-1481
2011
-
-
1
-
-
-
11
-
1
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2
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1
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1
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9
-
11
-
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1
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11
11
9
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1
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1
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717375
Piovan
Structure-activity relationshi ...
Homo sapiens
Bioorg. Med. Chem.
19
2009-2014
2011
-
-
-
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-
6
-
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1
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1
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6
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1
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707590
Elie
Identification and pre-clinica ...
Homo sapiens
Biochimie
92
1618-1624
2010
-
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1
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1
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1
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707591
Sevenich
Expression of human cathepsin ...
Homo sapiens
Biochimie
92
1674-1680
2010
-
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1
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1
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4
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4
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1
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4
-
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1
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1
1
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707626
Coppini
Plasminogen hydrolysis by cath ...
Homo sapiens
Biol. Chem.
391
561-570
2010
-
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1
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1
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1
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1
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7
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1
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7
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6
6
709133
Renko
Versatile loops in mycocypins ...
Homo sapiens
J. Biol. Chem.
285
308-316
2010
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1
1
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2
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3
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707906
Cheng
The cystatin M/E-controlled pa ...
Homo sapiens
Br. J. Dermatol.
161
253-264
2009
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1
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3
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18
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2
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18
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1
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1
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-
709405
Zeeuwen
The biology of cystatin M/E an ...
Homo sapiens
J. Invest. Dermatol.
129
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2009
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1
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3
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3
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3
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1
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1
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3
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1
1
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683210
Puzer
Cathepsin V, but not cathepsin ...
Homo sapiens
Biol. Chem.
389
195-200
2008
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1
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1
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2
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1
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1
1
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1
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1
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1
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1
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1
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1
1
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2
-
1
-
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-
1
-
-
-
-
-
-
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-
698753
Mihelic
Inhibitory fragment from the p ...
Homo sapiens
J. Biol. Chem.
283
14453-14460
2008
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1
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1
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1
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683207
Burden
Inhibition of cathepsin L-like ...
Homo sapiens
Biol. Chem.
388
541-545
2007
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1
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1
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2
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1
1
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1
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1
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Brmme
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