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Literature summary for 3.4.22.43 extracted from

  • Keegan, P.M.; Wilder, C.L.; Platt, M.O.
    Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation (2012), Mol. Cell. Biochem., 367, 65-72.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
x * 35000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60911
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic endothelial cell
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Homo sapiens

Expression

Organism Comment Expression
Homo sapiens tissue necrosis factor alpha increases cathepsin V expression and activity by 2fold. Tissue necrosis factor alpha and co-culturing with THP-1 monocytes stimulates a 460% increase in cathepsin V active enzyme up