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Literature summary for 3.4.22.43 extracted from

  • Wilder, C.L.; Park, K.Y.; Keegan, P.M.; Platt, M.O.
    Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues (2011), Arch. Biochem. Biophys., 516, 52-57.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
cathepsin V with mutated glycosylation site is expressed in Pichia pastoris Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
E-64
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23000
-
x * 23000, nonglycosylated form, SDS-PAGE Homo sapiens
35000
-
x * 35000, glycoprotein, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 23000, nonglycosylated form, SDS-PAGE Homo sapiens
? x * 35000, glycoprotein, SDS-PAGE Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4 6 cathepsin V is active at pH 4.0 and 6.0 Homo sapiens