Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.43 extracted from

  • Mihelic, M.; Dobersek, A.; Guncar, G.; Turk, D.
    Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation (2008), J. Biol. Chem., 283, 14453-14460.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular modeling of complex with fragment p41 of major histocompatibility complex class II-associated invariant chain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fragment p41 of major histocompatibility complex class II-associated invariant chain inhibitory to human cathepsin V, cathepsin L, cathepsin K, cathepsin F with Ki values in the low nanomolar range. Ki values are sufficiently low to ensure complex formation at physiological concentrations. Regulation of the proteolytic activity of most of the cysteine cathepsins by the p41 fragment is an important and widespread control mechanism of antigen presentation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000000072
-
fragment p41 of major histocompatibility complex class II-associated invariant chain pH 6.0, 25°C Homo sapiens