Crystallization (Comment) | Organism |
---|---|
molecular modeling of complex with fragment p41 of major histocompatibility complex class II-associated invariant chain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fragment p41 of major histocompatibility complex class II-associated invariant chain | inhibitory to human cathepsin V, cathepsin L, cathepsin K, cathepsin F with Ki values in the low nanomolar range. Ki values are sufficiently low to ensure complex formation at physiological concentrations. Regulation of the proteolytic activity of most of the cysteine cathepsins by the p41 fragment is an important and widespread control mechanism of antigen presentation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000000072 | - |
fragment p41 of major histocompatibility complex class II-associated invariant chain | pH 6.0, 25°C | Homo sapiens |