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Literature summary for 3.4.22.43 extracted from

  • Cheng, T.; Hitomi, K.; van Vlijmen-Willems, I.M.; de Jongh, G.J.; Yamamoto, K.; Nishi, K.; Watts, C.; Reinheckel, T.; Schalkwijk, J.; Zeeuwen, P.L.
    Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification (2006), J. Biol. Chem., 281, 15893-15899.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cystatin M/E cystatin M/E wild-type and mutant N64A show high affinity for cathepsin V, but not cystatin M/E mutant W135A Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
Homo sapiens
-
stratum corneum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the human transglutaminase zymogen is no substrate for the enzyme Homo sapiens ?
-
?
Z-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Z-Leu-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
CTSV
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000034
-
mutant N64A cystatin M/E pH 5.5, 22°C Homo sapiens
0.00000047
-
wild-type cystatin M/E pH 5.5, 22°C Homo sapiens