BRENDA - Enzyme Database show
show all sequences of 3.4.22.43

Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L

Puzer, L.; Cotrin, S.S.; Alves, M.F.; Egborge, T.; Araujo, M.S.; Juliano, M.A.; Juliano, L.; Broemme, D.; Carmona, A.K.; Arch. Biochem. Biophys. 430, 274-283 (2004)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Homo sapiens
0.0006
-
2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0006
-
2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0008
-
2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0012
-
2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0016
-
2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0017
-
2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.002
-
2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
best substrate
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
best substrate
667305
Homo sapiens
2-aminobenzoyl-KLR + SIKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KLRSXKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Ile, kinetics, detailed overview
667305
Homo sapiens
2-aminobenzoyl-KLR + SXKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KLRXSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Val, kinetics, detailed overview
667305
Homo sapiens
2-aminobenzoyl-KLR + XSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KLXSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Arg, kinetics, detailed overview
667305
Homo sapiens
2-aminobenzoyl-KLX + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KXRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Leu, kinetics, detailed overview
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-XLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Ala, kinetics, detailed overview
667305
Homo sapiens
?
-
-
-
?
kininogen fragments + H2O
kininogenase activity with high and low molecular weight kininogens
667305
Homo sapiens
?
Lys-bradykinin is the major product
-
-
?
additional information
substrate and cleavage site specificity of activated recombinant enzyme, comparison to cathepsin L, overview
667305
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Homo sapiens
0.6
-
2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.9
-
2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.3
-
2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.3
-
2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.5
-
2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.7
-
2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
4
-
2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6.5
assay at
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Homo sapiens
0.0006
-
2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0006
-
2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0008
-
2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0012
-
2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0016
-
2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.0017
-
2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.002
-
2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
best substrate
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
best substrate
667305
Homo sapiens
2-aminobenzoyl-KLR + SIKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KLRSXKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Ile, kinetics, detailed overview
667305
Homo sapiens
2-aminobenzoyl-KLR + SXKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KLRXSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Val, kinetics, detailed overview
667305
Homo sapiens
2-aminobenzoyl-KLR + XSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KLXSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Arg, kinetics, detailed overview
667305
Homo sapiens
2-aminobenzoyl-KLX + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-KXRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Leu, kinetics, detailed overview
667305
Homo sapiens
?
-
-
-
?
2-aminobenzoyl-XLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
X is varied with diverse amino acids, highest activity with Ala, kinetics, detailed overview
667305
Homo sapiens
?
-
-
-
?
kininogen fragments + H2O
kininogenase activity with high and low molecular weight kininogens
667305
Homo sapiens
?
Lys-bradykinin is the major product
-
-
?
additional information
substrate and cleavage site specificity of activated recombinant enzyme, comparison to cathepsin L, overview
667305
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Homo sapiens
0.6
-
2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
0.9
-
2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.3
-
2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.3
-
2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.5
-
2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
1.7
-
2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
4
-
2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine
recombinant enzyme, pH 5.5, 37°C
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6.5
assay at
Homo sapiens
Other publictions for EC 3.4.22.43
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732591
Wong
CTSL2 is a pro-apoptotic targe ...
Homo sapiens
Oncogene
33
1249-1257
2014
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
731213
McCarthy
-
Cathepsin L proteases of the p ...
Lepeophtheirus salmonis
Aquaculture
356-357
264-271
2012
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731573
Skrzypczak
Expression of cysteine proteas ...
Homo sapiens
Cancer Invest.
30
398-403
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
732049
Funkelstein
Human cathepsin V protease par ...
Homo sapiens
J. Biol. Chem.
287
15232-15241
2012
-
-
-
-
-
-
-
-
1
-
1
2
-
3
-
-
-
-
-
4
-
-
5
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
4
-
-
5
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
732502
Keegan
Tumor necrosis factor alpha st ...
Homo sapiens
Mol. Cell. Biochem.
367
65-72
2012
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
732867
Novinec
A simple and efficient protoco ...
Homo sapiens
Protein Expr. Purif.
82
1-5
2012
1
-
1
-
-
-
1
2
-
-
1
1
-
2
-
-
1
-
-
-
-
-
4
1
-
-
-
2
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
2
-
-
1
1
-
-
-
1
-
-
-
-
4
1
-
-
-
2
-
-
-
-
-
-
-
-
2
2
717159
Wilder
Manipulating substrate and pH ...
Homo sapiens
Arch. Biochem. Biophys.
516
52-57
2011
-
-
1
-
-
-
1
-
-
-
2
1
-
2
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
717374
Severino
Acridone alkaloids as potent i ...
Homo sapiens
Bioorg. Med. Chem.
19
1477-1481
2011
-
-
1
-
-
-
11
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
9
-
11
-
-
1
-
-
-
-
11
11
9
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717375
Piovan
Structure-activity relationshi ...
Homo sapiens
Bioorg. Med. Chem.
19
2009-2014
2011
-
-
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707590
Elie
Identification and pre-clinica ...
Homo sapiens
Biochimie
92
1618-1624
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707591
Sevenich
Expression of human cathepsin ...
Homo sapiens
Biochimie
92
1674-1680
2010
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
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1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707626
Coppini
Plasminogen hydrolysis by cath ...
Homo sapiens
Biol. Chem.
391
561-570
2010
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
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