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Literature summary for 3.4.22.43 extracted from

  • Santamaria, I.; Velasco, G.; Cazorla, M.; Fueyo, A.; Campo, E.; Lopez-Otin, C.
    Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas (1998), Cancer Res., 58, 1624-1630.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the predominant expression in thymus suggests a role in the immune system, the expression in testes suggests a role in fertilization processes, the expression in cancer cells together with its absence in normal cells suggests a role in tumor processes ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein three potential N-lycosylation sites Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
breast adenocarcinoma cell ZR-75-1, Hs-578T, MDA-MB435 Homo sapiens
-
SW-480 cell
-
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the predominant expression in thymus suggests a role in the immune system, the expression in testes suggests a role in fertilization processes, the expression in cancer cells together with its absence in normal cells suggests a role in tumor processes Homo sapiens ?
-
?
N-benzyloxycarbonyl-L-Arg-4-methylcoumarin 7-amide + H2O very low activity Homo sapiens N-benzyloxycarbonyl-L-Arg + 7-amino-4-methylcoumarin
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide + H2O very low activity Homo sapiens N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
-
Homo sapiens N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
?