Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corneocyte | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
citrulline-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | citrulline + 7-amino-4-methylcoumarin | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | interferon-gamma significantly reduces the expression of bleomycin hydrolase. The enzyme activity and expression are markedly decreased in atopic dermatitis lesional and non-lesional skin (to 27.1 and 8.8%, respectively) | down |
Homo sapiens | interleukin-4 does not show any direct effect on bleomycin hydrolase expression | additional information |
Homo sapiens | bleomycin hydrolase expression is up-regulated via IRF-1/2, MZF-1 and Sp-1. mRNA is up-regulated in keratinocytes when cultured at high calcium concentration (6.8fold) | up |