Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48000 | - |
6 * 48000, SDS-PAGE | Homo sapiens |
48000 | - |
6 * 48000, SDS-PAGE | Rattus norvegicus |
280000 | - |
gel filtration | Homo sapiens |
280000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bleomycin + H2O | Homo sapiens | - |
? | - |
? | |
bleomycin + H2O | Rattus norvegicus | - |
? | - |
? | |
deiminated filaggrin + H2O | Homo sapiens | neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids | ? | - |
? | |
deiminated filaggrin + H2O | Rattus norvegicus | neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme 4300fold from newborn rat epidermis by gel filtration, and two steps of anion exchange chromatography | Homo sapiens |
native enzyme 4300fold from newborn rat epidermis by gel filtration, and two steps of anion exchange chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | from newborn rats | Rattus norvegicus | - |
epidermis | the enzyme co-localizes with fillagrin in the granular layer, immunohistochemic analysis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bleomycin + H2O | - |
Homo sapiens | ? | - |
? | |
bleomycin + H2O | - |
Rattus norvegicus | ? | - |
? | |
bleomycin + H2O | from rat | Rattus norvegicus | ? | - |
? | |
citrulline-beta-naphthylamide + H2O | - |
Homo sapiens | citrulline + beta-naphthylamine | - |
? | |
citrulline-beta-naphthylamide + H2O | - |
Rattus norvegicus | citrulline + beta-naphthylamine | - |
? | |
deiminated filaggrin + H2O | neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids | Homo sapiens | ? | - |
? | |
deiminated filaggrin + H2O | neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids | Rattus norvegicus | ? | - |
? | |
deiminated filaggrin + H2O | recombinant human filaggrin is a component of the cornified cell envelope and the precursor of free amino acids acting as a natural moisturizing factor in the stratum corneum. Profilaggrin is synthesized as a large, extremely insoluble phosphoprotein. Deimination is critical for the degradation of filaggrin into free amino acids, deimination of filaggrin is catalyzed by murine PAD3 | Homo sapiens | ? | - |
? | |
deiminated filaggrin + H2O | recombinant human filaggrin is a component of the cornified cell envelope and the precursor of free amino acids acting as a natural moisturizing factor in the stratum corneum. Profilaggrin is synthesized as a large, extremely insoluble phosphoprotein. Deimination is critical for the degradation of filaggrin into free amino acids, deimination of filaggrin is catalyzed by murine PAD3 | Rattus norvegicus | ? | - |
? | |
additional information | bleomycin hydrolase is a neutral cysteine protease, the enzyme releases various amino acids except Pro from beta-naphthylamide derivatives and hydrolyzed citrulline-beta-naphthylamide most effectively, overview | Homo sapiens | ? | - |
? | |
additional information | bleomycin hydrolase is a neutral cysteine protease, the enzyme releases various amino acids except Pro from beta-naphthylamide derivatives and hydrolyzed citrulline-beta-naphthylamide most effectively, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | 6 * 48000, SDS-PAGE | Homo sapiens |
hexamer | 6 * 48000, SDS-PAGE | Rattus norvegicus |
More | trypsin-mediated peptide mapping, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
citrulline aminopeptidase | - |
Homo sapiens |
citrulline aminopeptidase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
the enzyme is most active at neutral pH | Homo sapiens |
additional information | - |
the enzyme is most active at neutral pH | Rattus norvegicus |