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Literature summary for 3.4.22.40 extracted from

  • Towne, C.F.; York, I.A.; Watkin, L.B.; Lazo, J.S.; Rock, K.L.
    Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses (2007), J. Immunol., 178, 6923-6930.
    View publication on PubMed
Search for more literature for 3.4.22.40

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus role in generating MHC class I-presented peptides suggested ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R016 bleomycin hydrolase-deficient cells from mice
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast cell line MEFs, bleomycin hydrolase-deficient cells from mice Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 bleomycin hydrolase-deficient mice unimpaired in epitope presentation from N-extended precursors or whole antigens, expression of normal levels of MHC class I molecules observed, in vivo CD8 T cell responses to eight epitopes from three different viruses unaffected, redundancy with other aminopeptidases in predicted role on antigen presentation determined Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information role in generating MHC class I-presented peptides suggested Mus musculus ?
-
 ?
additional information role of bleomycin hydrolase in antigen presentation and in generation of CD8 T cell response analyzed in bleomycin hydrolase-deficient mice Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
BH protein
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 Mus musculus